SH-14B vs. Pyrilutamide vs. Clascoterone

Published on October 22, 2026 at 7:15 AM

Bibebibebibe Research

Special Feature Issue

SH-14B

Provisional #63/859,365

Tetracyclic Core (Bent-Arm)

Primary Mechanism Steric Helix 12 Blockade

Binding Affinity (Ki) ~2.8 nM

Target Partitioning LogP ≈ 3.4 (Pilosebaceous)

Pyrilutamide

KX-826 / Koshine

Thiohydantoin / Pyridinyl

Primary Mechanism Competitive AR Displacement

In Vitro IC50 ~0.28 nM

Phase 3 TAHC Gain +15.33 hairs/cm²

Clascoterone

Breezula 5%

Steroidal Cortexolone Derivative

Primary Mechanism Tissue AR Inhibition

In Vitro IC50 ~50 nM

Systemic Protection Esterase Hydrolysis

Target-Site Steric Efficiency Score

SH-14B (Helix 12 Disruption) 92%

Pyrilutamide (Competitive Binding) 85%

Clascoterone (Local Steroidal Action) 60%

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